Sodium sulfobutylether β-cyclodextrin

Product Name: Betadex Sulfobutylether sodium;SBE-β-CD;SBECD
CAS No.: 182410-00-0
Cat. No.: ZY-003
MWt: 1451.29
Formula: C50H84Na2O41S2
Purity : 98%
Solubility: Water > 100 mg/ml

Usage β-Cyclodextrin with sulfobutyl ether groups and sodium ions substituted along the length of the molecule. β-Cyclodextrin is a cyclic oligosaccharide produced from starch via enzymatic conversion. β-C yclodextrin is commonly used to produce HPLC columns allowing chiral enantiomers separation.
Usage SBE- β -CD is a chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.
Synonyms: .beta.-Cyclodextrin, sulfobutyl ethers, sodium salts;Sodium sulfobutylether β-cyclodextrin;Betadex Sulfobutyl Ether Sodium ;sulfobutyl ether B-cyclodextrin;sodiuM salts;sulfobutyl ethers;SodiuM Sulphobutylether-β-Cyclodextrin
Biological Activity:
SBE-β-CD (Sulfobutylether-β-Cyclodextrin; Captisol) is a chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs; Captisol is the trademark of SBE-β-CD registered by Ligand Pharmaceuticals.
IC50 value:
Target: Drug adjuvant
SBE-β-CD is a unique reproducible mixture of polyanionic β-cyclodextrin derivatives in which a sodium sulfonate salt is tethered to the lipophilic cyclodextrin cavity by a butyl ether group, or sulfobutylether (SBE). The sulfobutyl ether (SBE) substituent is introduced at the 2, 3, and 6 positions in one or more of the glucopyranose units in the cyclodextrin structure. The introduction of SBE substituents onto the β-cyclodextrin can produce preparations with different overall average degrees of substitution due to the proportion of multiple species present with different degrees of substitution, theoretically from 1 to 21 sites for substitution. SBE-β-CD, with on average 7 such SBE substituents per β-cyclodextrin, introduced by way of a reproducible patent-protected process, was chosen as the cyclodextrin preparation with the most desirable safety profile and drug association properties.